Professional interest in female sexual dysfunction (FSD) has evolved rapidly with the FDA approval of several landmark treatments. Studies indicate that approximately 43% of American women experience some form of sexual dysfunction, with Hypoactive Sexual Desire Disorder (HSDD) being the most common complaint. The highest proportion occurs in young women between the ages of 18 and 29. (Updated clinical data from the Journal of Women’s Health and the FDA now provides a clearer roadmap for pharmacological intervention in pre- and postmenopausal women.) The lack of desire appears to be the number one, most significant complaint, followed by arousal and lubrication dysfunctions.
Twenty-one percent of those surveyed experienced physical pain during sex, while 27 percent reported that intercourse was not enjoyable. Sixteen percent admitted to sexual anxiety. The prevalence of female sexual dysfunction continues to be documented and the topic has generated discussions in both the medical and lay communities (60 Minutes, Larry King, Newsweek, Oprah).
Male sexual dysfunction has received the lion’s share of interest, but women’s complaints have been virtually ignored. Thankfully, that trend seems to be changing. With the advent of Viagra, the JAMA report and women’s demands, drug companies are investigating drug treatments for women with sexual dysfunction. We know that there will not be a magic pill to cure sexual dysfunction, but we do have hope for the future. While clinical investigations take time, we anticipate the study of female sexual dysfunction will advance so all women can benefit from treatment. While medications are effective, many patients see optimal results when combining drug therapy with regenerative options like the O-Shot treatment for low libido.
The latest drugs that show promise in treating female sexual dysfunction problems are listed in our comprehensive table by
- name
- drug manufacturer
- key ingredient
- current or potential use
- clinical trial status
Some treatments are available now by prescription; others are still in clinical trial phases. If you suffer from female sexual dysfunction, see your doctor. You may want to bring a copy of this chart to show your doctor that there are courses of treatment available. The drugs listed as “available by prescription only” must be obtained through your doctor. We will continue to update this chart as new treatments become available.
| Drug/Product | Generic Name | Primary Use | FDA Status |
| Addyi® | Flibanserin | Treats low sexual desire (HSDD) by balancing neurotransmitters (Dopamine/Serotonin). | FDA Approved (Premenopausal & Postmenopausal <65) |
| Vyleesi® | Bremelanotide | An injectable “as-needed” treatment for low sexual desire (HSDD) used 45 mins before sex. | FDA Approved (Premenopausal) |
| Intrarosa® | Prasterone | A daily vaginal insert (DHEA) to treat moderate to severe pain during intercourse (dyspareunia). | FDA Approved |
| Osphena® | Ospemifene | An oral pill (SERM) that helps thicken vaginal tissue to reduce painful intercourse. | FDA Approved |
| Eros-CTD® | Device | A clitoral therapy device that increases blood flow and sensation via gentle suction. | FDA Approved (Available by Prescription) |
| Estrace/Premarin | Estrogen | Localized creams or rings used to treat vaginal dryness and atrophy. | FDA Approved |
| Testosterone | Compounded | Often prescribed “off-label” to improve libido, energy, and sensitivity in women. | Available via Compounding Pharmacy |
Understanding Hypoactive Sexual Desire Disorder (HSDD)
HSDD is the medical term for a persistent or recurrent lack of interest in sex that causes personal distress or relationship strain. Unlike a temporary “dry spell,” HSDD is a biological condition related to the balance of neurotransmitters in the brain. Dr. Jennifer Berman specializes in diagnosing the root causes of HSDD, whether they are hormonal, neurological, or lifestyle-related.
Frequently Asked Questions
Q: Is there a “Viagra for women”? While Viagra (Sildenafil) works on blood flow, female treatments like Addyi and Vyleesi work on the brain’s desire pathways. However, Sildenafil is sometimes prescribed “off-label” for certain female arousal disorders.
Q: Can hormone therapy help with sexual dysfunction? Yes. For many women, especially during menopause, a drop in estrogen or testosterone leads to dryness and low desire. Bioidentical Hormone Replacement Therapy (BHRT) is a key component of a comprehensive treatment plan.
Q: How do I know if I need a prescription or a procedure? During your consultation, we evaluate if your symptoms are best treated with medication (like Addyi) or regenerative procedures such as the O-Shot® or Vaginal Rejuvenation to improve physical sensation and comfort.
For women experiencing physical discomfort or laxity, we also offer non-surgical Vaginal Rejuvenation and Forma V treatments to complement your prescription plan.
Additional resources on female sexuality are available from MayoClinic.com:
https://www.mayoclinic.org/healthy-lifestyle/womens-health/in-depth/kegel-exercises/art-20045283
https://www.mayoclinic.org/healthy-lifestyle/sexual-health/basics/womens-sexual-health/hlv-20049432
https://www.mayoclinic.org/healthy-lifestyle/womens-health/basics/womens-health/hlv-20049411
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